文献：Preparation and Characterization of Folate-Targeted Fe3O4 Nanoparticle Codelivering Cisplatin and TFPI-2 Plasmid DNA for Nasopharyngeal Carcinoma Therapy

作者：Juan Zhang, Huanhuan Weng, Xiangwan Miao, Quanming Li, Siqi Wang, Huifen Xie, Tao Liu, Minqiang Xie

文献链接：//onlinelibrary.wiley.com/doi/full/10.1155/2017/2849801

摘要：

Proper particle diameter [25, 26] and positive surface charge of nanodrug play an important role in cellular uptake of drug and enhancement target-oriented effects [17]. The particle size of FA-PEG-PEI@SPION-CDDP-TFPI-2 complexes was determined using TEM (Figure 4(a)). TEM micrograph illustrated monodisperse spherical particles with an average diameter of 55.2 ± 8.4 nm, the sizes of which contribute to avoiding phagocytosis by macrophages, renal excretion, and aggregation in the bone marrow. There were several SPION particles at an average diameter of 8 nm arranged as a ring inside the complex. Negligible sedimentation was observed in the complex liquid with one-year observation, which suggested excellent stability of the system. The TEM EDS in Figure 4(b) verified the presence of Pt and Fe elements in FA-PEG-PEI@SPION-CDDP-TFPI-2 complexes, suggesting a potent combination between CDDP and SPION. The Fe content and CDDP loading amount were 5.35 mg/ml and 100 ug/ml, respectively, as counted according to corresponding standard curves by colorimetry.

微米性类药的合适粒度和正外面电势在上皮细胞摄入性类药和怎强靶向药物效果中起突出要功能。粒度FA-PEG-PEI@SPION-CDDP-TFPI-2使用的TEM检测法pp物。TEM显微图片视频表现了一般长度为55.2±8.4毫米的单扩散球体颗料 nm，其大大小小能助杜绝巨噬生殖细胞的毁灭效应、肾脏脂肪代谢和骨髓中的聚集地。有三个一般长度为8毫米的SPION颗料 nm在pp物内排列三成环。经每年的留意，在更复杂的药液中留意到可轻视的凝固，这表达该系統还具有优秀的可靠性。TEM EDS核实了Pt和Fe金属元素在FA-PEG-PEI@SPION-CDDP-TFPI-2包覆物，证明CDDP和SPION两者之间会出现很好的紧密联系。铁的含量和CDDP阻抗量为5.35 mg/ml和100 ug/ml，可根据特定的基准曲线方程经过比色法记数。涉及推荐英文：mPEG-PLGA(1K)mPEG-PLGA(10K)mPEG-PLGA(20K)mPEG-PEI(1K)mPEG-PCL(1K)mPEG-PLGA(2K)mPEG-PLGA(4K)mPEG-PiperazinemPEG-PLA(10K)mPEG-PLA(5K)mPEG-C18H37mPEG-GlutathionemPEG-HistidinemPEG-PSBmPEG-PLGA(5K)mPEG-DTPA以上的好文章信息内容源头各种类型论文期刊或论文参考文献，要是有抄袭请电话联系让我们刪除！