期刊论文：磷脂修饰语的PEI基微米承载采用内部siRNA*多药抗药*友链：//www.nature.com/articles/gt201497小说作者：埃塞克斯郡东部G纳瓦罗P·萨巴钱达尼，表层结构膜M Trivedi，S Movassaghian＆总经理裁托尔奇林节选：三维线瘤中P-糖淀粉酶质过体现介导的多药耐药理功能性(MDR)是多放疗放疗失败的的最主要环境因素。本分析考核了磷脂遮盖的分低子量聚氯乙烯亚胺(DOPE-PEI)奈米的质粒适用于静脉注谢输送带*P-糖淀粉酶质siRNA至*的功能，最中梦想是房产调控甲状腺炎癌的MDR。第一个，当我门分析了DOPE-PEI奈米的质粒的生物工程区域划分相应PEG耐磨涂层在皮内甲状腺炎*模式化中的功能。注谢后四钟头，PEG化的质粒使用明显增强的融合性和残留相互作用，在三维线瘤中累积了8%的注谢含水量(ID)，由PEG介导的循环往复时段延长至，在血清中累积了22%的ID。第二步，当我门认定了DOPE-PEI/siRNA介导的P-gp下降联和阿霉素(Dox)放疗放疗在MCF-7/MDR异种胚胎移植瘤中的辽效和安全卫生性。应当每周都注谢siRNA奈米注射剂和Dox，维持将近5周，使*对在原本不正确含水量的Dox有过敏性，并使*体积大概与较组相比较变小了二倍。这样的对Dox辽效的可以改善归因于DOPE-PEI注射剂介导的做手术*中特殊的回文序列特异形P-gp下降。

Multidrug resistance (MDR) mediated by P-glycoprotein overexpression in solid tumors is a major factor in the failure of many forms of chemotherapy. Here we evaluated phospholipid-modified, low-molecular-weight polyethylenimine (DOPE-PEI) nanocarriers for intravenous delivery of anti-P-pg siRNA to tumors with the final goal of modulating MDR in breast cancer. First, we studied the biodistribution of DOPE-PEI nanocarriers and the effect of PEG coating in a subcutaneous breast tumor model. Four hours postinjection, PEGylated carriers showed an 8% injected dose (ID) accumulation in solid tumor via the enhanced permeability and retention effect and 22% ID in serum due to a prolonged, PEG-mediated circulation. Second, we established the therapeutic efficacy and safety of DOPE-PEI/siRNA-mediated P-gp downregulation in combination with doxorubicin (Dox) chemotherapy in MCF-7/MDR xenografts. Weekly injection of siRNA nanopreparations and Dox for up to 5 weeks sensitized the tumors to otherwise non-effective doses of Dox and decreased the tumor volume by threefold vs controls. This therapeutic improvement in response to Dox was attributed to the significant, sequence-specific P-gp downregulation in excised tumors mediated by the DOPE-PEI formulations.杭州杏彩体育平台 生态学作为重要性货品：DSPE-PyreneDSPE-ThiolDSPE-PEG-GE11(二硬脂酰基磷脂酰工业乙醇胺-聚乙二醇-*体细胞外皮的生长细胞EGFR靶向治疗肽)DSPE-PEG-HisDSPE-PEG-cRGD(二硬脂酰基磷脂酰工业乙醇胺-聚乙二醇-组合素靶点环肽)ALC-0315DOPE-PEG-MalDSPE-PEG-M2pepDSPE-PEG-cisplatinDSPEGPC3靶向治疗肽-PEG-DSPE超过软文网站内容原因常见论文期刊或文献综述，烦请侵犯商标权请找话题咱们删掉！