参考文献：磷脂遮盖的PEI基纳米技术形式用以休内siRNA*多药耐药性*链接代码：//www.nature.com/articles/gt201497小说作者：埃塞克斯郡东部G纳瓦罗P·萨巴钱达尼，表层结构膜M Trivedi，S Movassaghian＆副ceo裁托尔奇林节选：实物瘤中P-糖蛋清过表达出来介导的多药耐药肺结核性(MDR)是很多放手术失败的的重要条件。本实验测试了磷脂体现的分太低子量聚丁二烯亚胺(DOPE-PEI)nm的承载适用于静脉血管运送*P-糖蛋清siRNA至*的结果，终究对方是管控乳线癌癌的MDR。一方面，让当我们实验了DOPE-PEInm的承载的生物体规划已经PEG耐磨涂层在皮下组织乳线癌*建模方法中的的作用。注入后四小时英文，PEG化的承载经过提升的加入性和滞留旅客调节作用，在实物瘤中积少成多了了8%的注入用药量(ID)，基于PEG介导的嵌套循环时间间隔调长，在血清中积少成多了了22%的ID。而后，让当我们确保了DOPE-PEI/siRNA介导的P-gp变动联动阿霉素(Dox)放手术在MCF-7/MDR异种囊胚移植瘤中的见效和安全的性。每一周注入siRNAnm注射剂和Dox，保持将近5周，使*对本来面目不正确用药量的Dox引起皮肤比较敏感状态，并使*球体积与对比组差距缩小许多了五倍。在这种对Dox见效的调节归因于DOPE-PEI注射剂介导的去除*中正相关的编码序列特情人P-gp变动。

Multidrug resistance (MDR) mediated by P-glycoprotein overexpression in solid tumors is a major factor in the failure of many forms of chemotherapy. Here we evaluated phospholipid-modified, low-molecular-weight polyethylenimine (DOPE-PEI) nanocarriers for intravenous delivery of anti-P-pg siRNA to tumors with the final goal of modulating MDR in breast cancer. First, we studied the biodistribution of DOPE-PEI nanocarriers and the effect of PEG coating in a subcutaneous breast tumor model. Four hours postinjection, PEGylated carriers showed an 8% injected dose (ID) accumulation in solid tumor via the enhanced permeability and retention effect and 22% ID in serum due to a prolonged, PEG-mediated circulation. Second, we established the therapeutic efficacy and safety of DOPE-PEI/siRNA-mediated P-gp downregulation in combination with doxorubicin (Dox) chemotherapy in MCF-7/MDR xenografts. Weekly injection of siRNA nanopreparations and Dox for up to 5 weeks sensitized the tumors to otherwise non-effective doses of Dox and decreased the tumor volume by threefold vs controls. This therapeutic improvement in response to Dox was attributed to the significant, sequence-specific P-gp downregulation in excised tumors mediated by the DOPE-PEI formulations.郑州杏彩体育平台 生物制品提供数据相关的产品设备：DSPE-PyreneDSPE-ThiolDSPE-PEG-GE11(二硬脂酰基磷脂酰无水乙醇胺-聚乙二醇-*体细胞表层生长的成分EGFR靶向治疗肽)DSPE-PEG-HisDSPE-PEG-cRGD(二硬脂酰基磷脂酰乙酸乙酯胺-聚乙二醇-兼容合并素靶点环肽)ALC-0315DOPE-PEG-MalDSPE-PEG-M2pepDSPE-PEG-cisplatinDSPEGPC3靶向疗法肽-PEG-DSPE往上小文章知识的来源几大类学术期刊或学术论文，如果发现侵权商标请连接我们大家删掉！