表面层上的缔合物-多肽/淀粉酶质共聚物

本文作者详述了外观共价接枝的多肽/蛋白酶质的合成图片策略极其机械、化学上分析措施技术性。获得了此种外壁接枝的一般策略涵盖配位聚苯胺链的“嫁接起(grafting to)”或“枝接于(grafting from)”工艺，在这之后再粘附肽/核胆固醇。或就可以将现做的合成视频物移植成功到表明上。

Abstract：

Background: Polymer-peptide/protein conjugates immobilized on surface have gained considerable attention, mostly due to their broad scope of applications in biomedical fields. To optimize their properties, the combined knowledge of polymer chemistry and biochemistry has to be applied.

Method: The main methods to obtain such surfaces involve “grafting to” or “grafting from” of polymeric linkers with subsequent attachment of a peptide/protein. Alternatively, a “ready-made” conjugate may be grafted to the surface.

Result: The structure of the polymer linker significantly influences the properties of the active surface, and a variety of physicochemical methods and tools have been successfully applied to study the structure-property relationship of these surfaces.

Conclusion: This review outlines the applied synthetic strategies leading to covalently attached bioconjugates on the surface and the characterization techniques used to study those materials. The relevance of different linear polymeric linkers and their influence on the properties of the obtained materials is discussed.