抗体药物偶联物(ADC)的抗体靶点/连接臂的选择条件
绵阳杏彩体育平台 生态学作为各种设计和功效的不同拼接子,能够用于表面抗原和治疗类药的偶联的拼接子。公司可不可以将治疗类药可以控制地偶联到表面抗原上,
抗原偶联用量(Antibody–drug conjugates (ADCs))应该基本概念为药物剂量前体,抗原就可以识別展示**抗原的靶点,并利用连结子与神经元*素的“弹头”偶联形成针对**细胞的靶向递送系统。
两个期望的ADC药物需要四个部分结合:
抵抗能力(靶点)的选购:对应**特异(相关联)性抗原,较高的把你想表达出来品质,好的的内吞学习效率、好的的抗原沟通协调能力、无免役原性、制剂可及性;
衔接臂的挑选:血渍循环法中始终保持安全,在神经细胞内快脱离,施放*物;
连到习惯:选点偶联,诞生均一的抵抗能力偶联物;
*素氧分子:基本规定要求*素充足的强,高于单利用使IC50<1nmol;足够的水溶性及血清中的稳定性;*物的作用靶点位于细胞内。
表面抗原偶联药材成分形式
杏彩体育平台 生物技术为客人提高不相同大规模的, 应用在的概念认证(POC)的免疫表面抗原阳性中成药偶联物很快偶联展示 业务。大家便用神经元*素,外部链接子和偶联方式的展示 个人定制免疫表面抗原阳性中成药偶联物展示 业务。主要包括全部完整详细的免疫表面抗原阳性中成药偶联物解析意见书
善长于Seattle Genetics方法步骤偶联
因为半胱氨酸
擅長于Immunogen形式偶联
针对赖氨酸
具备完整版的抗原中药偶联物表现进行分析工艺:
剖析生产工具:HPLC(HIC,SEC,RP),iCIEF,LC-MS
安全性能:用药与抗原比(DAR),利用SDS-PAGE研究的色度,多聚体,内*素,用量使用量
杏彩体育平台 动物出售抗原偶联药品连结子名录:
物产品称谓称 | 类产品cas |
Fmoc-Val-Cit-PAB | CAS:cas:159858-22-7 |
Fmoc-Val-Cit-PAB-PNP | CAS:cas:863971-53-3 |
Val-cit-PAB-OH | CAS:159857-79-1 |
Phe-Lys(Trt)-PAB | CAS:1116085-99-4 |
Fmoc-Phe -Lys(Trt)-PAB-PNP | CAS:1116086-09-9 |
Aloc-D-Ala-Phe-Lys(Aloc)-PAB-PNP | CAS:253863-34-2 |
Cbz‐Phe‐(Alloc)Lys‐PAB‐PNP | CAS:159857-90-6 |
Boc‐Phe‐(Alloc)Lys‐PAB‐PNP | CAS:1160844-44-9 |
N-SMP | CAS:55750‐61‐3 |
GMBS | CAS:80307-12-6 |
5-Maleimidovalericacid-NHS | CAS:103750-03-4 |
Mal-PEG4-NHS | CAS:1325208-25-0 |
Mal-PEG-NHS | CAS:1260092-50-9 |
5-hexynoic NHS ester | CAS:906564-59-8 |
NHS-PEG4-azide | CAS:944251-24-5 |
Bis-PEG1-NHS ester | CAS:65869-64-9 |
Bis-PEG2-NHS Ester | CAS:65869-63-8 |
Bis-PEG3-NHS Ester | CAS:1314378‐16‐9 |
NHS-PEG3-NHS | CAS:1314378-11-4 |
sulfo-LC-SPDP | CAS:150244‐18‐1 |
MAL-Tetra-EG-OPFP | CAS:1347750-84-8 |
Mal-PEG5-NHS | CAS:1315355-92-0 |
Mal-amido-PEG6-NHS | CAS:1137109-21-7 |
Maleimide-PEG8-NHS ester | CAS:756525-93-6 |
NHS-Ac-N3 | CAS:824426-32-6 |
NHS-PEG12-azide | CAS:1610796-02-5 |
Bis-PEG5-NHS ester | CAS:756526-03-1 |
Bis-PEG9-NHS ester | CAS:1008402-79-6 |
Boc-Val-Cit-PAB-PNP | CAS:870487-10-8 |
Alkyne-PEG-acid (PEG1-PEGn) | CAS:55683-37-9 |
Alkyne-PEG-NHS ester (PEG1-PEGn) | CAS:1174157-65-3 |
Alkyne-PEG-t-butyl ester (PEG1-PEGn) | CAS:488150-84-1 |
Alkyne-PEG-alcohol (PEG1-PEGn) | CAS:3973-18-0 |
Alkyne-PEG-bromide (PEG1-PEGn) | CAS:203740-63-0 |
Alkyne-PEG-Alkyne (PEG1-PEGn) | CAS:40842-04-4 |
Alkyne-PEG2-methylamine | CAS:1835759-76-6 |
Alkyne-PEG4-thiol | CAS:1347750-80-4 |
Alkyne-PEG4-5-nitrophenyl carbonate | CAS:1422540-81-5 |
Alkyne-PEG-methane (PEG1-PEGn) | CAS:89635-82-5 |
Alkyne-PEG4-(CH2)3-methyl ester | CAS:1872433-63-0 |
APN-C3-PEG4-alkyne | CAS:2183440-36-8 |
Alkyne-PEG2-acrylate | CAS:52436-42-7 |
Gly-PEG3-endo-BCN, TFA salt | CAS:2354291-37-3 |
Boc-Gly-PEG3-endo-BCN | CAS:2110444-63-6 |
Aminoethyl-SS-ethylalcohol | CAS:15579-01-8 |
Aminoethyl-SS-propionic acid | CAS:15579-00-7 |
Aminoethyl-SS-ethylamine | CAS:51-85-4 |
t-Boc-Cystamine | CAS:485800-26-8 |
N3-SS-PEG2-acid | CAS:2144777-72-8 |
N3-SS-propionic NHS ester | CAS:2243566-44-9 |
N3-SS-ethylalcohol | CAS:1807540-82-4 |
N3-SS-N3 | CAS:352305-38-5 |
N3-PEG3-SS-PEG3-N3 | CAS:1310827-27-0 |
N3-PEG2-t-Butyl ester | CAS:2144777-83-1 |
Alkyne-PEG1-SS-alcohol | CAS:1391914-41-2 |
Alkyne-PEG1-SS-PEG1-acid | CAS:1807503-85-0 |
Alkyne-PEG1-SS-PEG1-PFP ester | CAS:1817735-30-0 |
Alkyne-PEG1-SS-PEG1-Alkyne | CAS:1964503-40-9 |
Alkyne-PEG1-SS-PEG1-t-butyl ester | CAS:1807518-78-0 |
Acid-PEG-SS-PEG-acid (PEG1-PEGn) | CAS:1807539-10-1 |
Boc-NH-ethyl-SS-propionic acid | CAS:485800-27-9 |
Boc-aminooxy-ethyl-SS-propanol | CAS:2128735-21-5 |
Fmoc-NH-ethyl-SS-propionic acid | CAS:864235-83-6 |
Fmoc-NH-ethyl-SS-propionic NHS ester | CAS:2128735-23-7 |
Mal-NH-ethyl-SS-propionic acid | CAS:2128735-24-8 |
Hydroxy-PEG3-SS-PEG3-alcohol | CAS:5662-81-7 |
THP-SS-alcohol | CAS:877864-04-5 |
THP-SS-PEG1-t-butyl ester | CAS:1807503-88-3 |
THP-SS-PEG1-Tos | CAS:1807512-37-3 |
2-hydroxyethyl disulfide mono-Tosylate | CAS:1807530-16-0 |
Bis-Tos-(2-hydroxyethyl disulfide) | CAS:69981-39-1 |
N3-SS-biotin | CAS:1620523-64-9 |
DBCO-SS-PEG3-biotin | CAS:1430408-09-5 |
Biotin-bisamido-SS-NHS | CAS:142439-92-7 |
NHS-SS-biotin | CAS:122266-55-1 |
Sulfo-NHS-SS-biotin | CAS:325143-98-4 |
PC Biotin-PEG3-alkyne | CAS:1869922-24-6 |
PC Biotin-PEG3-N3 | CAS:1937270-46-6 |
PC Biotin-PEG3-NHS carbonate ester | CAS:2353409-93-3 |
PC Alkyne-PEG4-NHS carbonate ester | CAS:1802907-98-7 |
PC Methyltetrazine-PEG4-NHS carbonate ester | CAS:1408057-91-9 |
PC N3-PEG11-NHS carbonate ester | CAS:2353409-91-1 |
Mal-PEG2-Val-Cit-PAB-OH | CAS:2055041-38-6 |
Mal-PEG1-Val-Cit-PAB-PNP | CAS:2249935-92-8 |
Mal-amido-PEG2-Val-Cit-PAB-PNP | CAS:2112738-13-1 |
N3-PEG3-Val-Cit-PAB-OH | CAS:2055024-65-0 |
N3-PEG3-Val-Cit-PAB-PNP | CAS:2055047-18-0 |
BCN-PEG3-VC-PFP Ester | CAS:2353409-45-5 |
Methylamino-PEG-acid (PEG1-PEGn) | CAS:1367918-21-5 |