ICG maleimide马来酰亚胺,ICG-MAL,吲哚菁绿

英语翻译名：ICG maleimide，ICG-MAL
中文版名：吲哚菁绿-马来酰亚胺
的外观：有机咖啡豆
溶解性度：二氯甲烷气体
饱和度：95%+
设备构造式：

ICG maleimide马来酰亚胺,ICG-MAL,吲哚菁绿

ICG is a tricarbocyanine-type dye with NIR-absorbing properties (peak absorption around 800 nm) and emission maximum at 807 nm (10% v/vDMSO/PBS). Little absorption in the visible range accounts for the low autofluorescence, tissue absorbance, and scattering at NIR wavelengths (700-900 nm).

The maleimide of the ICG dye offers the opportunity to develop optimal conjugates. Maleimide active group provides an efficient and convenient way to selectively link ICG dye to sulfhydryl groups (free thiol, R-SH) on various substrates (antibodies[1], peptides, proteins, oligonucleotides, small molecule drugs etc.) at neutral (physiological) pH without any activation. Maleimides have very low reactivity with amines, alcohols, and phenols (incl. tyrosine and histidine) and do not react with histidine and methionine thus providing very high labeling selectivity.

It has been reported that conjugation to some antibodies may cause decrease in fluorescence intensity of ICG bound to antibody due to the formation of H-dimers4. However, fluorescence is restored after cell binding and internalization, which can be used to design an activatable NIR fluorescent probe. Fluorescence intensity of the unbound ICG-antibody conjugate can be dramatically increased (up to 50-fold) by addition of SDS and β-mercaptoethanol, which diminishes π- π stacking5.

涉及到品牌：

TCO-PEG-ICG   吲哚菁绿-聚乙二醇-反式环辛炔

ICG-PEG4-Thiol

ICG-PEG4-NHS

ICG-PEG5-NH2

ICG-PEG4-MAL

ICG-PL-PEG  磷脂化的聚乙二醇

ICG-PL-PEG-FA ICG-PEG-Folate 吲哚菁绿-聚乙二醇-叶酸片

ICG-FA-PPD  吲哚菁绿-备孕叶酸掩盖PEI-PEG-钆酸

RGD-PLS-ICG  吲哚菁绿-RGD装饰聚乙二醇化脂质体

C18-PEG-ICG

ICG-PEG-Silane 吲哚菁绿-聚乙二醇-硅烷

ICG-PEG-Lipoic acid,  ICG-PEG-LA吲哚菁绿-聚乙二醇-硫苦不堪言

ICG-PEG-Epoxides (EPOX) 吲哚菁绿-聚乙二醇-环氧防锈漆化物

ICG-PEG-Valeric Acids (VA) 吲哚菁绿-聚乙二醇-缬草酸

ICG-PEG-Chloride 吲哚菁绿淡化聚乙二醇氯化物

ICG-PEG-TZ/Tetrazine  吲哚菁绿修饰语聚乙二醇四嗪

ICG-PEG-CHEMS 吲哚菁绿绘制聚乙二醇半虎珀酸碳水化合物

ICG-PEG-DBCO  吲哚菁绿修饰语聚乙二醇环辛炔

CG-PEG-ICG  吲哚菁绿-聚乙二醇-壳聚糖

ICG-PEG-Chitosan   吲哚菁绿-聚乙二醇-壳聚糖

ICG-PEG-Dextran   吲哚菁绿遮盖聚乙二醇葡聚糖/右旋糖酐

ICG-PEG-Galactose  吲哚菁绿体现聚乙二醇半乳糖

ICG-PEG-Mannose   杨枝糖

ICG-PL-PEG-mAb 数据整合素α(v)β₃单克隆免疫抗体

APT-PEG-ICG-Der-02   MUC1适体的靶配体APT-聚乙二醇-吲哚菁绿

ICG-PEG-MTX  甲氨蝶呤

ICG-PEG-DOX  阿霉素

GNR-PEG-ICG  納米金棒-聚乙二醇-吲哚菁绿

GNR-PEG-ICG-FA微米金棒-聚乙二醇-吲哚菁绿-DHA

Cu9S5@mSiO2-ICG-PEG-LA 核壳成分介孔二空气氧化硅纳米级塑料再生颗粒-吲哚菁绿-聚乙二醇-硫苦不堪言

PEG-PCL-C3-ICG-NPs    PEG-PCL加巧妙类化合物C3-ICG的納米粒

双职能ICG繁衍物ICG-PEG8-Sulfo-OSu

双的功能ICG具象化物ICG-PEG4-Sulfo-OSu

ICG随之出现物ICG-Sulfo-OSu

ICG-PL-PEG 磷脂化的聚乙二醇

ICG-PL-PEG-FA孕妇叶酸 磷脂化的聚乙二醇

ICG-FA-PPD 吲哚菁绿-叶酸片装饰PEI-PEG-钆酸

RGD-PLS-ICG 吲哚菁绿-RGD修饰语聚乙二醇化脂质体

ICG-PEG-Lipoic acid, ICG-PEG-LA吲哚菁绿-聚乙二醇-硫心酸

ICG-PEG-TZ/Tetrazine 吲哚菁绿掩盖聚乙二醇四嗪

ICG-PEG-DBCO 吲哚菁绿体现聚乙二醇环辛炔

CG-PEG-ICG 吲哚菁绿-聚乙二醇-壳聚糖