专著：Preparation and Characterization of Folate-Targeted Fe3O4 Nanoparticle Codelivering Cisplatin and TFPI-2 Plasmid DNA for Nasopharyngeal Carcinoma Therapy小说家：Juan Zhang, Huanhuan Weng, Xiangwan Miao, Quanming Li, Siqi Wang, Huifen Xie, Tao Liu, Minqiang Xie资料外部链接：//onlinelibrary.wiley.com/doi/full/10.1155/2017/2849801引言：considered the cross-coupling reaction between the above cationic carriers and nonionic water-soluble polymers PEG to increase the solubility and decrease aggregation of the composites. Besides that, the combination between CDDP and aldehyde sodium alginate modified SPION is more capable of adsorbing PEG modified PEI via electrostatic interaction due to the improved biocompatibility, water-solubility, and longer circulation time in blood. Meanwhile, the targeting FA-PEG-PEI was prepared by amidation reaction between the carboxyl groups of FA and amino groups of NH2-PEG-OH. Finally, FA-PEG-PEI@SPION-CDDP-TFPI-2 nanocomplex was performed by linking FA-PEG-PEI with SPION-CDDP and CDDP according to appropriate proportion. In vitro assay demonstrated the superiority of the nanocomplex in specific targetability for FR+ tumors.

考虑的了这些阳阴阴亚铁离子媒体或非阴阴亚铁离子水可溶解性高，溶于水的性聚合表现物PEG范围内的交叉重合偶联表现，以提高了塑料物料的可溶解性高，溶于水的度并才能减少密集。于此，仍然动物相匹配性、水可溶解性高，溶于水的性和血管嵌套循环事件更长，CDDP和醛-海苔酸钠体现的SPION范围内的組合更能凭借防静电互相反应吸附性PEG体现的PEI。一同，借助FA的羧基与NH2-PEG-OH的氨基范围内的酰胺化表现制作了靶向疗法FA-PEG-PEI。最好，FA-PEG-PEI@SPION-CDDP-TFPI-2借助将FA-PEG-PEI与SPION-CDDP和CDDP按相当比率连结，确定纳米级复合材料物的制作。体内疲劳试验表示，奈米塑料物在FR+淋巴肿瘤的特女性朋友靶向药物性几个方面具有着优秀性。相应的推薦：Trt-PEG-OHBn2-PEG-OHBr-CH2CO-NH-PEG-OHOH-PEG-RGDOH-PEG-CH2COOtBuS-Acetyl-PEG-OHDA-PEG-OHBr-PEG-OHDBCO-PEG-OHHZ-PEG-OHPhthalimide-PEG-OH综上所述句子文章来原分类学术期刊或文献综述，予以知识产权侵权请找话题我国误删！