文献综述：Preparation and Characterization of Folate-Targeted Fe3O4 Nanoparticle Codelivering Cisplatin and TFPI-2 Plasmid DNA for Nasopharyngeal Carcinoma Therapy小说家：Juan Zhang, Huanhuan Weng, Xiangwan Miao, Quanming Li, Siqi Wang, Huifen Xie, Tao Liu, Minqiang Xie参考文献地址：//onlinelibrary.wiley.com/doi/full/10.1155/2017/2849801提要：Our previous study has revealed that TFPI-2 is expressed at a low level in NPC cells and tissues [16]. As proof of concept we use FA as targeting molecules, which conjugated to amino-terminated polyethylene glycol (NH2-PEG-COOH) and polyethylenimine (PEI) to perform cationic polymers (FA-PEG-PEI) via amidation. Aldehyde sodium alginate modified Fe3O4 magnetic particles coated cisplatin (SPION-CDDP) was constructed with the above cationic polymer to obtain composite carriers (FA-PEG-PEI@SPION-CDDP), which then adsorbed TFPI-2 pDNA via electrostatic interaction to obtain the FA-targeted, CDDP, and TFPI-2-coated nanocomposites (FA-PEG-PEI@SPION-CDDP-TFPI-2). In vitro assays indicated that the novel compounds possessed excellent load-carrying capacity and drug stability and showed negligible cytotoxicity and enhanced targetability to FR positive (FR+) NPC HNE-1 cells.

探讨表面，TFPI-2在鼻咽恶性肿瘤核和团体中的传达层次较低。做一个理论依据认证，我们都适用FA做一个靶向药物原子核，它与氨基封的聚乙二醇（NH2-PEG-COOH）和聚氯乙烯亚胺（PEI）共轭，进行酰胺化产生阳铝离子聚合反应物（FA-PEG-PEI）。用上面的阳正离子聚合反应物搭配了醛-海藻颗粒酸钠改性的材料的Fe3O4吸引力物体包复顺铂（SPION-CDDP），以提升包覆各种载体(FA-PEG-PEI@SPION-CDDP)，后来会通过电磁干扰双方帮助吸咐TFPI-2 pDNA，提升FA靶向疗法治疗、CDDP和TFPI-2涂覆的nm包覆的材料(FA-PEG-PEI@SPION-CDDP-TFPI-2).身体之外冲击试验表达，新氧化物极具市场大的的安装程度和中药可靠性，对FR阳型（FR+）NPC HNE-1血细胞系的血细胞系致毒会删去不算，靶向疗法治疗性增強。有关的强烈推荐：OH-PEG-CH2COOtBuS-Acetyl-PEG-OHDA-PEG-OHBr-PEG-OHDBCO-PEG-OHHZ-PEG-OHPhthalimide-PEG-OHPLL-PEG-OHPLGA(10K)-PEG-OHSilane-PEG-OH及以上经典文章相关内容的来源多种论文期刊或文献资料，如不侵犯著作权请连接我们大家删了！