期刊论文：传递必备条件下可生态学降解塑料微球与组织上皮细胞指数修改密码内皮组织上皮细胞的特情人黏附性跳转：//etd.ohiolink.edu/acprod/odb_etd/etd/r/1501/10?clear=10&p10_accession_num=ohiou1040071303我：达拉尔，米林德·K节选：抽象性的在多病症生态环境中，各方面内皮组织吸附原子 (ECAM) 的描述依然会增高，这可使得哪些原子拥有定项类药递送规划的有能吸电磁力的靶点。一种生活措施是在使用中有 mAb 的高分子化合物物可生态学溶解微球来靶向药物性药物描述增高的 ECAM。.我借助生态学素-亲和素药剂学措施将 mAb 与 E-首选素或 ICAM-1 偶联到由生态学素化的聚乳酸-聚乙二醇 (PLA-PEG-生态学素) 共聚物制造而成的微球上。.我考试了所得的 mAb 包被的可生态学溶解科粒孩子与父母脐冠状动脉内皮组织 (HUVEC) 的吸附性。.我看见，mAb 包被的 PLA-PEG-生态学素微球对 4 小時后 E-首选素和 ICAM-1 描述平均技术水平较高的 IL-1β 缴活的 HUVEC 的吸附高朝于对不描述 E-首选素且 ICAM-1 描述平均技术水平较低的未缴活 HUVEC 的吸附性。.我还看见吸附力依靠于切面热应力。因此，.我看见*E-首选素包被微球对4小時IL-1β缴活的HUVEC的首选性与用在形成*E-首选素包被微球的*E-首选素氧浓度密切合作有关。哪些成果表述，包被有*ECAM单克隆*体的PLA-PEG-生态学素科粒要用在首选性地将类药靶向药物性药物细菌感染器官的内皮组织。

AbstractIn a variety of disease settings the expression of various endothelial cell adhesion molecules (ECAMs) appears to be increased, making these molecules attractive targets for directed drug delivery schemes. One approach is to use polymeric biodegradable microspheres bearing a mAb for an ECAM whose expression is increased. We used biotin-avidin chemistry to couple a mAb to E-selectin or ICAM-1 to microspheres made from a biotinylated poly (lactic acid) poly (ethylene glycol) (PLA-PEG-biotin) copolymer. We tested the adhesion of the resulting mAb coated biodegradable particles to human umbilical vein endothelial cells (HUVEC). We found that the mAb coated PLA-PEG-biotin microspheres show high specific adhesion to 4 hr. IL-1β activated HUVEC expressing high levels of E-selectin and ICAM-1 relative to the level of adhesion to unactivated HUVEC that express no E-selectin and a low level of ICAM-1. We also found that the adhesion was shear stress dependent. Additionally, we have found that the selectivity of anti-E-selectin coated microspheres to 4 hr. IL-1β activated HUVEC is a strong function of the concentration of anti-E-selectin used to generate the anti-E-selectin coated microspheres. These results suggest that PLA-PEG-biotin particles coated with mAbs to ECAMs could be used to selectively target drugs to endothelium present at sites of inflammation.广州杏彩体育平台 生物制品展示相应厂品：mPEG-PLAPLA-PEG-SCFA-PEG-PLAMal-NH-PEG-PLAMal-PEG-PLAGalactose-PEG-PLA左右软文资源由来常见期刊杂志或文章，若有图片侵权请结合我国卸载！