论文：Palladium cubes with Pt shell deposition for localized surface plasmon resonance enhanced photodynamic and photothermal therapy of hypoxic tumors†作著：Wenxiang Gu ab, Zhiyuan Hua b, Zheng Li ab, Zhiheng Cai a, Wandong Wang a, Kaijin Guo b, Feng Yuan b, Fenglei Gao ORCID logo*a and Hongliang Chen论文外链：//pubs.rsc.org/en/content/articlehtml/2022/bm/d1bm01406d引言：Multifunctional phototherapy nanoagents for imaging-guided synergistic photothermal therapy (PTT) and photodynamic therapy (PDT) are highly desirable in the field of solid tumor therapy. Nevertheless, the tumor microenvironment (TME) inherently associated with hypoxia significantly hampers the photodynamic effect of these multifunctional nanoagents. Herein, Pd nanocubes coated with an ultrathin Pt shell were prepared and further conjugated with fluorescein labeled and thiol functionalized polyethylene glycol (FITC-PEG-SH) (denoted as Pd@Pt-PEG). The deposition of a Pt shell on Pd nanocubes not only enhances the photothermal performance, exhibiting excellent hyperthermia outcomes and impressive photothermal (PT) imaging quality, but also leads to the formation of singlet oxygen (1O2) induced by plasmonic excitation. In the meantime, the catalytic activity of the Pt layer is enhanced by electronic coupling and the plasmonic effect, which induces the decomposition of endogenous overexpressed hydrogen peroxide (H2O2) in tumors to generate O2 for conquering TME and augmenting 1O2 generation for efficacious tumor cell apoptosis. The modification of FITC-PEG-SH improves the biocompatibility and provides outstanding fluorescence (FL) imaging properties. Upon NIR laser irradiation, Pd@Pt-PEG allows in situ O2 generation and dual-mode imaging-guided synergistic PTT/PDT that effectively kills hypoxic tumor cells, which makes it a promising nanotherapeutic agent for enhanced tumor therapy.

用做显像引导系统的信息化光热保健法（PTT）和光发动机保健法（PDT）的多性能光疗納米剂在实体型瘤治療区域受受追捧。虽然，与缺养固定性关联的恶性肿瘤微条件（TME）显著性阻拦了这一些多性能納米药物治疗的光发动机效用。在这种，提纯了涂有纤薄Pt壳的Pd微米立米体，并举第一步与荧光素标志和巯基官能化的聚乙二醇（FITC-PEG-SH）（带表为Pd@Pt-PEG).Pt壳在Pd微米立米体上的的堆积不禁增強了光性温能，突出表现出良好的热药用价值果和另人映像印象深刻的光热（Pt）显像品质，且还以至于等阴阳离子体提升介导的单线态氧（1O2）的形成了。与此同时，Pt层的催化剂的作用吸附性满足电子无线交叉耦合和等阳离子体作用获得增进，这诱惑了良性肉瘤中内源性过描述的过阳极氧化氢（H2O2）的分析，会引起O2以占据TME，并加强1O2的会引起以满足效果的良性肉瘤细胞系凋亡。FITC-PEG-SH的改善改善了海洋生物混溶性，并展示 了优异的荧光（FL）三维成像安全性能。在NIR皮秒激光阳光照射下，Pd@Pt-PEG容许原位O2自动生成和双模显像修复系统的协同工作PTT/PDT，合理有效毒杀缺氧症状淋巴肺部肿瘤组织细胞，这使其称得上增加淋巴肺部肿瘤治療的有行业发展前景的微米治療剂。有关推薦：FITC-PEG-DTPAFITC-PEG-EstrogenFITC-PEG-LAFITC-PEG-MTXFITC-PEG-NiacinFITC-PEG-OPSSFITC-PEG-PCL(2K)FITC-PEG-PCL(5K)FITC-PEG-ProgestroneFITC-PEG-SCFITC-PEG-SilaneFITC-PEG-TretinoinICG-PEG-AlkyneICG-PEG-Biotin之上方面方面起源种类中文核心期刊或论文，要是有侵权行为请认识人们清空！