参考文献：Targeted folic acid-PEG nanoparticles for noninvasive imaging of folate receptor by MRI写作者：Ting-Jung Chen, Tsan-Hwang Cheng, Yu-Chin Hung, Kuei-Tang Lin, Gin-Chung Liu, Yun-Ming Wang文章环节：//onlinelibrary.wiley.com/doi/abs/10.1002/jbm.a.31752结语：The surface of superparamagnetic iron oxide nanoparticles (SPIO) with different molecular weight of poly(ethylene glycol) (PEG) and folic acid (FA) were synthesized. The SPIO-PEG-FA nanoparticles are well-dispersed and have good stability in various pH solutions. The lack of hysterestis and remanence at ambient temperatures is characteristic of superparamagnetic materials for SPIO-PEG-FA. The uptake by macrophage for SPIO-PEG-FA is lower than that of Feridex I.V. even at higher concentration. Internalization of SPIO-PEG-FA in targeted cells (KB cells) was observed by flow-cytometric analysis and in vitro MR imaging. The intensity change of positive KB cell tumor (−20 to 25%) is significantly lower than that of negative HT-1080 cell tumor from precontrast to postcontrast images of the tumor by in vivo MR imaging. These preliminary results demonstrated that SPIO-PEG-FA have the ability to target folate receptor.  

获得了区别大分子量聚乙二醇（PEG）和DHA（FA）的超顺带磁氧化反应铁奈米微粒（SPIO）漆层。SPIO-PEG-FA奈米微粒疏散优良，在多种pH水溶液中都具有优良的不稳界定性。在生态湿度下匮乏磁滞和剩磁是SPIO-PEG-FA的超顺磁铁材质的特色。只不过在越来越高的溶液浓度下，巨噬神经血细胞系核对SPIO-PEG-Fe的摄食也少于Feridex I.V。完成流式的神经血细胞系核术阐述和身体之外MR激光散斑观查SPIO-PEG-FA在靶神经血细胞系核（KB神经血细胞系核）中的内化。能够里面MR显像，从癌症的造影前画像到造影后画像，呈阳性KB人体生殖细胞癌症的标准变动（-20%至25%）很大高出假阳性HT-1080人体生殖细胞癌症。此类首次毕竟证明，SPIO-PEG-FA具备着靶点DHA多巴胺受体的性能。相关联推见：FITC-PEG-AzithromycinFITC-PEG-CHOFITC-PEG-DTPAFITC-PEG-EstrogenFITC-PEG-LAFITC-PEG-MTXFITC-PEG-NiacinFITC-PEG-OPSSFITC-PEG-PCL(2K)FITC-PEG-PCL(5K)FITC-PEG-ProgestroneFITC-PEG-SCFITC-PEG-SilaneFITC-PEG-TretinoinICG-PEG-Alkyne以内优秀文章主要内容来源地分类刊物或医学文献，告之知识产权侵权请去联系企业移除！