论文参考文献：Easy formulation of liposomal doxorubicin modified with a bombesin peptide analogue for selective targeting of GRP receptors overexpressed by cancer cells写作者：Antonella Accardo, Silvia Mannucci, Elena Nicolato, Federica Vurro, Carlo Diaferia, Pietro Bontempi, Pasquina Marzola & Giancarlo Morelli文献综述网页链接：//link.springer.com/article/10.1007/s13346-018-00606-x内容提要：The article concerns the obtainment of liposomal doxorubicin (Dox) in which liposomes are externally modified with a targeting peptide able to drive the formulation in a selective way on membrane receptors overexpressed in tumors. We developed a kit composed by three different vials: (A) a vial containing a sterile, translucent, red dispersion of the liposomal doxorubicin drug (Doxil®), (B) a vial filled with a lyophilized powder of a modified phospholipid with a reactive function (DSPE-Peg-maleimide), and (C) a vial containing a 1–9 bombesin peptide analogue (Cys-BN-AA1) chemically modified to react in stoichiometric ratio respect to DSPE-Peg-maleimide. The chosen peptide is a stable analogue antagonist of the wild-type 1–9 bombesin peptide; it is very stable in serum; maintains high specificity, with nanomolar affinity, towards gastrin release peptide receptors (GRPRs indicated also as BB2); and is overexpressed in some cancer cells. Results on animal studies clearly indicate that in mice treated with the kit product (i.e., pegylated liposomal Dox modified with the bombesin analogue, Doxil-BN-AA1), tumor growth is reduced, with an improved efficacy respect to mice treated with non-modified pegylated liposomal Dox or with saline solution.

今天相关阿霉素脂质体（Dox）的收获，中间脂质体用靶向疗法肽完成内部掩盖，是可以以决定性的方法在良性癌症中过表达方法方式的膜肾上腺素多巴胺受体上驱动安装剂型。咱们建设好几个种由4个区别小瓶主成的生物制剂盒：（a）另一款 具备着阿霉素脂质体药剂（Doxil®）没有细菌、半透明体、紫色分散型体的小瓶，（B）另一款 装着具备着化学反应迟钝的功能的改良磷脂（DSPE-Peg maleimide）冻干颗粒的小瓶，已经（C）另一款 包含有1-9蛙皮素肽内似物（Cys-BN-AA1）的小瓶，该内似物经过了生物掩盖，可与DSPE-Peg-maleimid以生物剂量比化学反应迟钝。相应肽是也是型1-9蛙皮素肽的动态平衡内似物拮抗剂；在血清中越来越动态平衡；对胃泌素移除肽肾上腺素多巴胺受体（GRPR也称做BB2）增加高特男人，具备着纳摩尔亲和；和在一定肝癌人体细胞中过表达方法方式。节肢动物科研可是看清楚地体现了，会用生物制剂盒商品（即用蛙皮素内似物Doxil-BN-AA1掩盖的聚乙二醇化脂质体Dox）疗法的小鼠中，良性癌症衍生才能减少，与用非掩盖聚乙二醇化脂质体质备Dox或生理方面建议使用淡盐水配合疗法的小鼠相对比，见效为政者增长。相关的推荐英文：DSPE-PEG-THDSPE-PEG-YIGSRDSPE-PEG-NGRDSPE-PEG-Angiopep-2DSPE-PEG-CREKADSPE-PEG-RVG29DSPE-PEG-M2pep以上的的文章项目起源各种类型论文期刊或论文参考文献，告之知识产权侵权请搞好关系我们都卸载！