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mPEG-EPO共聚AzPheEO制备及结构表征
发布时间:2025-07-16     作者:kx   分享到:
资料:聚乙二醇接枝光化学反应性聚乙二醇的生成与定量分析非常在防生物制品污损应用因素的深入分析下载链接://www.mdpi.com/2073-4360/15/1/184笔者:马哈茂德·H·奥斯曼1,2奥西德,伊藤义弘1,2,3,*奥西德和秋元准节选:EO、AzPheEO和mPEG-EPO的共聚前提是,将丙稀酸乙烷 (EO) 与 AzPheEO 和 mPEG-EPO 共聚(措施 1)。因为,将 TBAB、AzPheEO 和 mPEG-EPO 在真空室下皮肤晾干 2 钟头,第三暴露自己于皮肤晾干离氮气中。将甲苯下载到烧瓶中以融化 mPEG-EPO。其次,将 EO 饱和水稀硫酸和 i-Bu 3 Al 下载到放置在冰浴中的烧瓶中。将饱和水稀硫酸在 25 °C 下阴凉搅拌机共聚 18 钟头。将甲醇下载到饱和水稀硫酸中,心理减压除开萃取剂。将粗氧化物融化于二甲苯中,并将饱和水稀硫酸用清水透析半年。第三将所得额税率水滑石物急冻皮肤晾干,誉为 AzPEGx [y],进来 x 和 y 分为主要 Mn 和 mPEG-EO 的喂料比。所得额税率 AzPEGx [y] 水滑石物选择1 H-核磁震荡 (NMR) 光谱讲解法 (JNM-ECZ400R, 400 MHz, JEOL, 日地区日大阪) 在氯仿中做定性讲解,及及选择凝露融入色谱法 (GPC; JASCO, 日地区日大阪) 做定性讲解。该设备装备每台光折射率查重器 (RI-2032, JASCO, 日地区日大阪) 和2根液相色谱柱 (SB-803 HQ 和 SB804 HQ; Showa Denko, 日地区日大阪),在有 10 mM 溴化锂的二甲基甲酰胺 (DMF) 中做讲解。

mPEG-EPO

 Copolymerization of EO, AzPheEO, and mPEG-EPOFirst, EO was copolymerized with AzPheEO and mPEG-EPO (Scheme 1). For this, TBAB, AzPheEO, and mPEG-EPO were dried under vacuum for 2 h, after which they were exposed to dry nitrogen. Toluene was added to the flask to dissolve mPEG-EPO. Subsequently, the EO solution and i-Bu3Al were added to the flask in an ice bath. The solution was stirred for copolymerization at 25 °C in the dark for 18 h. Methanol was added to the solution, and the solvent was removed under reduced pressure. The crude compound was dissolved in acetone, and the solution was dialyzed against water for three days. The resulting polymer was then freeze-dried and is referred to as AzPEGx [y], where x and y represent the Mn and feed ratio of mPEG-EO, respectively. The obtained AzPEGx [y] polymer was characterized via 1H-nuclear magnetic resonance (NMR) spectroscopy (JNM-ECZ400R, 400 MHz, JEOL, Tokyo, Japan) in chloroform, as well as via gel permeation chromatography (GPC; JASCO, Tokyo, Japan). The system was equipped with a refractive index detector (RI-2032, JASCO, Tokyo, Japan) and two columns (SB-803 HQ and SB804 HQ; Showa Denko, Tokyo, Japan) in dimethylformamide (DMF) containing 10 mM lithium bromide.陕西杏彩体育平台 生物制品作为相关软件:DOPCDSPE-PEG-MannoseDSPE-PEG-RhodamineDOPE-PEG-SCDSPE(Sodium salt)-PEG-COOHDOPE-PEG-MalDSPE-PEG-多肽(几种订制)DSPE-PEG-Ce6上面句子信息内容收入常见学术期刊或文献资料,要是有商标侵权请连接小编删除图片!