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DSPE-PEG-RGD修饰脂质体用于增强siRNA在视网膜色素上皮细胞中的摄取
发布时间:2025-07-15     作者:kx   分享到:
医学文献:多功能 RGD-脂质共轭淡化脂质体适用增强人角膜色斑上皮细胞膜中 siRNA 的递送外部链接://www.tandfonline.com/doi/full/10.2147/IJN.S24447小编:陈成伟,卢大文,叶明公,萧嘉阳&蒋介石节选:镶嵌了种环保型的多功能性脂质DSPE-PEG-RGD,其空间结构为Arg(R)-Gly(G)-Asp(D)肽基与1,2-二硬脂酰-sn-甘油-3-磷酸酒精胺-N-[马来酰亚胺(聚乙二醇)-2000]偶联。该脂质体适用于制法载siRNA的RGD-PEG化脂质体,以促进眼底黄斑色素沉淀上皮癌细胞对siRNA的摄食。制法了分离包含的1 mol%和5 mol% PEG化脂质或者1 mol%和5 mol% RGD-PEG化脂质的很多种脂质体。

DSPE-PEG-RGD

A novel functional lipid, DSPE-PEG-RGD, a Arg(R)-Gly(G)-Asp(D) motif peptide conjugated to 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine- N-[maleimide (polyethylene glycol)-2000], was synthesized for the preparation of siRNA-loaded RGD-PEGylated liposomes to enhance uptake of encapsulated siRNA in retinal pigment epithelial cells. Various liposomes, with 1 mol% and 5 mol% PEGylated lipid or 1 mol% and 5 mol% RGD-PEGylated lipid, were fabricated.杭州杏彩体育平台 怪物给予关于服务:DSPE-PEG-6-O-glucoseCy3-iRGD-PEG-DSPERGD-PEG-COOHDOPE-PEIcRGD-PEG-COOHmPEG-Cholesterol (mPEG-CLS)DPPE-PEG2-NH-Mal以上介绍论文介绍来源地几大类论文期刊或文献综述,如不图片侵权请关系小编删了!