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基于DSPE-PEG-RGD的siRNA靶向递送脂质体制备
发布时间:2025-07-14     作者:kx   分享到:
医学文献:新式 RGD-脂质共轭呈现脂质体采用增强人眼底黄斑天然色素上皮组织细胞中 siRNA 的递送链接转换://www.tandfonline.com/doi/full/10.2147/IJN.S24447#d1e278作家:陈成伟,卢大文,叶明公,萧嘉阳&蒋介石节选:组成打了个种新式的功能模块性脂质DSPE-PEG-RGD,其结构设计为Arg(R)-Gly(G)-Asp(D)肽基与1,2-二硬脂酰-sn-甘油-3-磷酸工业乙醇胺-N-[马来酰亚胺(聚乙二醇)-2000]偶联。该脂质体在准备载siRNA的RGD-PEG化脂质体,以增强学习视膜色素沉淀上皮体细胞对siRNA的摄食。准备了各是含带1 mol%和5 mol% PEG化脂质并且 1 mol%和5 mol% RGD-PEG化脂质的多个脂质体。

DSPE-PEG-RGD

MethodsA novel functional lipid, DSPE-PEG-RGD, a Arg(R)-Gly(G)-Asp(D) motif peptide conjugated to 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine- N-[maleimide (polyethylene glycol)-2000], was synthesized for the preparation of siRNA-loaded RGD-PEGylated liposomes to enhance uptake of encapsulated siRNA in retinal pigment epithelial cells. Various liposomes, with 1 mol% and 5 mol% PEGylated lipid or 1 mol% and 5 mol% RGD-PEGylated lipid, were fabricated.石家庄杏彩体育平台 怪物提拱一些设备:DSPE-PEG-ACDSPE-PEG-OHDSPE-PEG-Anti-rat CC531mAb(二硬脂酰基磷脂酰无水乙醇胺-聚乙二醇-良性肿瘤靶向疗法血清)DSPE-PEG-6-FAMDPPE-PEG-MalDSPE-PEG-DBCOFITC-iRGD-PEG-DSPEcRGD-PEG-N3及以上新闻稿件相关内容特征分类论文期刊或学术论文,要是有侵权商标请联络公司清空!