学术论文：两亲性mPEG-高密度脂蛋白共轭物的提炼、胶束化名词解释在姜黄素递送中的使用地址：//dspace.nitrkl.ac.in/dspace/handle/2080/3725做者：普拉丹、艾斯瓦娅·帕特尔、萨比塔节选：肺癌是全世界*知名的消化道疾病，自今未曾赢得冶好。诸多的实验考生和能够家就已经 强调了许多步骤来除根肺癌，即协力*模式和加入几种药剂膜蛋白，如脂质体、纳米技术设备颗粒物、胶束等。这当中，汇聚物胶束是 药剂递送膜蛋白其所平衡性比较高、CMC 更低、溶于性好些、比从面能积小和生物制品混溶性好些而备受瞩目关心。方便将 PEG 基胶束配置成疏水药剂膜蛋白，咱们顺利采用缩真实流量分解了两亲性 mPEG-甘油三酯共轭物。便用 1H NMR、FTIR、HRMS 光谱界定定量定量剖析界定定量定量剖析对分解的汇聚物从面能吸附性剂实行了定量定量定量剖析。顺利采用紫外线可以可以看出光和荧光法界定定量定量剖析了许多分解从面能吸附性剂的胶束化道德行为。感觉这些装修标准的 CMC 在微摩尔比率内。以姜黄素为沙盘模型药剂，的实验了便用配置的平衡胶束实行疏水药剂的掺量和递送。与水物质中的姜黄素不同之处，姜黄素在胶束物质中的平衡性十分的高。估算求出的药剂负荷效应为 72%，可与其它的胶束装修标准相堪比。顺利采用 XRD 界定定量定量剖析印证了药剂的掺量。用 SEM 技术设备界定定量定量剖析了从面能形貌。从 DSC 热界定定量定量剖析图可以可以看出，负荷姜黄素的胶束的平衡性高出未负荷的胶束。药剂挥发保持的曲线印证了药剂的持续性挥发保持，这对肺癌*尤为重要的。还的实验了細胞充满活力和*癌吸附性。从有的基本结局去看，咱们配置的 mPEG-甘油三酯胶束装修标准被感觉也是种十分的有发展且能够的药剂递送膜蛋白。Cancer is a deadliest illness worldwide which is still not conquered. Several approaches have been made by various researchers and scientists to eradicate it by combined therapeutic modalities and introduction of number of drug carriers like liposomes, nanoparticles, micelles etc. Among them polymeric micelles as a drug delivery carrier has gained much more attention because of its greater stability, lower CMC, solubility, small size and biocompatibility. In an attempt to formulate PEG-based micelle as hydrophobic drug carrier, we have synthesized amphiphilic mPEG-Cholesterol conjugates by condensation method. The synthesized polymeric surfactants were characterised using 1H NMR, FTIR, HRMS spectral analysis. Micellization behaviour of these synthesized surfactants were analysed by UV-Vis and fluorescence method. The CMC of the above systems are found to be in the micro-molar range. Incorporation and delivery of hydrophobic drug using the formulated stable micelles was studied using curcumin as a model drug. The stability of curcumin was found to be very high in the micellar medium compared to the curcumin in aqueous medium. Drug loading efficiency was calculated and found to be 72% which can be comparable to the other micellar system. From the XRD analysis, the drug incorporation was confirmed. Surface morphology was analysed by using SEM technique. From the DSC thermograms, the stability of the curcumin loaded micelle was found to be higher than the unloaded micelle. Drug release profile confirmed a sustained release of drug which is vital for the cancer therapy. The cell viability and anticancer activity was also studied. From the overall results obtained, our formulated mPEG-Cholesterol micellar system found to be very promising and effective as drug delivery vehicles.

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