文献：基于甘草酸修饰的DSPE-PEG-PEI纳米粒联合递送阿霉素和Bcl-2 siRNA的肝靶向联合*

链接：//www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.00004/full

作者：Guixiang Tian，Ruiyan Pan&，Bo Zhang，Meihua Qu，LianBo Lian，Hong Jiang，Zhiqin Gao，Jingliang Wu

节选：

由于微米药递送模式的整合的治疗方法已开发已成为的一种有未来发展的方法，它融入了几种或几种**长效机制。本研究分析制得了由1,2-二硬脂酰-sn-甘油-3-磷酸乙酸乙酯胺-聚乙二醇-聚醚酰亚胺（DSPE-PEG-PEI）和甘草次酸淡化明亮质酸（GA-HA）根据的肝靶向治疗微米粒（GH-DPP），代替整合递送阿霉素（DOX）和Bcl-2 siRNA。旋光度的测定了载药GH-DPP納米粒（siRNA/DOX/GH-DPP）的粒度、zeta电势和型态。分析一下了其对HepG2体组织的体组织摄入和身体之外体组织致毒。在荷瘤小鼠中评价了siRNA/DOX/GH-DPP的身体内部海洋生物分布范围和***的效果。数据呈现，siRNA/DOX/GH-DPP納米粒呈近圆球形，对HepG2体组织具体表现出用药量依赖感性的体组织致毒。与重新递送DOX或Bcl-2 siRNA的无甘草次酸共递送系统化（siRNA/DOX/DPP）和GH-DPP微米粒优于，siRNA/DOX/GH-DPP微米粒也可以引诱更大细胞膜凋亡，并具体表流露出越高的**成果。GH-DPP微米粒也可以而且将化疗药口服药物和siRNA递运至*地域，在***中体流露出非常大的的前景。

译文：

Combination therapy based on nano-sized drug delivery system has been developed as a promising strategy by combining two or more anti-tumor mechanisms. Here, we prepared liver-targeted nanoparticles (GH-DPP) composed of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-polyetherimide (DSPE-PEG-PEI) with Glycyrrhetinic acid-modified hyaluronic acid (GA-HA) for co-delivery of doxorubicin (DOX) and Bcl-2 siRNA. Particles size, zeta potential and morphology were determined for the drug-loaded GH-DPP nanoparticles (siRNA/DOX/GH-DPP). Cellular uptake and in vitro cytotoxicity were analyzed against HepG2 cells. In vivo bio-distribution and anti-tumor therapeutic effects of siRNA/DOX/GH-DPP were evaluated in H22-bearing mice. The results showed that siRNA/DOX/GH-DPP nanoparticles were nearly spherical and showed dose-dependent cytotoxicity against HepG2 cells. Compared to Glycyrrhetinic acid-free co-delivery system (siRNA/DOX/DPP) and GH-DPP nanoparticles for delivery of DOX or Bcl-2 siRNA alone, siRNA/DOX/GH-DPP nanoparticles could induce more cellular apoptosis, and showed higher anti-tumor effect. Herein GH-DPP nanoparticles could simultaneously deliver both chemotherapy drugs and siRNA into the tumor region, exhibiting great potential in anti-tumor therapy.

石家庄杏彩体育平台 生态学出具关于产品的：Cy5-PEG-DPPEPeptides PEG PLADSPE-PEG-SP94iRGD-PEG-DSPEPTP-PEG-COOHAngiopep-2-PEG-N3DMPE-PEG-CY3cRGD-PEG-PLGA

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