文献：基于甘草酸修饰的DSPE-PEG-PEI纳米粒联合递送阿霉素和Bcl-2 siRNA的肝靶向联合*

链接：//www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2019.00004/full

作者：Guixiang Tian，Ruiyan Pan&，Bo Zhang，Meihua Qu，LianBo Lian，Hong Jiang，Zhiqin Gao，Jingliang Wu

节选：

应用场景納米中成药递送软件的聯合療法已发展壮大变成其中一种有就业前景的方式，它配合了两者或多**机理。本钻研配制了由1,2-二硬脂酰-sn-甘油-3-磷酸乙酸乙酯胺-聚乙二醇-聚醚酰亚胺（DSPE-PEG-PEI）和甘草次酸表达透明体质酸（GA-HA）构成的的肝靶向疗法納米粒（GH-DPP），主要用于聯合递送阿霉素（DOX）和Bcl-2 siRNA。测定法了载药GH-DPP奈米技术粒（siRNA/DOX/GH-DPP）的粒度数据分布、zeta电极电位和形状。研究了其对HepG2人体上皮受损神经元核的人体上皮受损神经元核摄食和身体人体上皮受损神经元核致癌性。在荷瘤小鼠中评诂了siRNA/DOX/GH-DPP的机体生物学数据分布和***疗效。结局认为，siRNA/DOX/GH-DPP奈米技术粒呈近圆柱状，对HepG2人体上皮受损神经元核表达出用量依靠性的人体上皮受损神经元核致癌性。与简单递送DOX或Bcl-2 siRNA的无甘草次酸共递送系统化（siRNA/DOX/DPP）和GH-DPPnm粒较之，siRNA/DOX/GH-DPPnm粒可诱骗一些受损细胞凋亡，并现象出高些的**成效。GH-DPPnm粒可一同将肺癌晚期化疗食用的药物和siRNA递送入*区域性，在***中展露出非常大的竟争力。

译文：

Combination therapy based on nano-sized drug delivery system has been developed as a promising strategy by combining two or more anti-tumor mechanisms. Here, we prepared liver-targeted nanoparticles (GH-DPP) composed of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-polyethylene glycol-polyetherimide (DSPE-PEG-PEI) with Glycyrrhetinic acid-modified hyaluronic acid (GA-HA) for co-delivery of doxorubicin (DOX) and Bcl-2 siRNA. Particles size, zeta potential and morphology were determined for the drug-loaded GH-DPP nanoparticles (siRNA/DOX/GH-DPP). Cellular uptake and in vitro cytotoxicity were analyzed against HepG2 cells. In vivo bio-distribution and anti-tumor therapeutic effects of siRNA/DOX/GH-DPP were evaluated in H22-bearing mice. The results showed that siRNA/DOX/GH-DPP nanoparticles were nearly spherical and showed dose-dependent cytotoxicity against HepG2 cells. Compared to Glycyrrhetinic acid-free co-delivery system (siRNA/DOX/DPP) and GH-DPP nanoparticles for delivery of DOX or Bcl-2 siRNA alone, siRNA/DOX/GH-DPP nanoparticles could induce more cellular apoptosis, and showed higher anti-tumor effect. Herein GH-DPP nanoparticles could simultaneously deliver both chemotherapy drugs and siRNA into the tumor region, exhibiting great potential in anti-tumor therapy.

石家庄杏彩体育平台 怪物打造各种相关物料：Cy5-PEG-DPPEPeptides PEG PLADSPE-PEG-SP94iRGD-PEG-DSPEPTP-PEG-COOHAngiopep-2-PEG-N3DMPE-PEG-CY3cRGD-PEG-PLGA

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