医学文献：使用的电子层力谱法估评束搏1-棕榈酰-2-油酰-sn-甘油-3-磷酸胆碱膜的杨氏模量网页链接：//pubs.acs.org/doi/abs/10.1021/jp505451h笔者：王曦，罗伯特·N·桑德森‡雷吉娜·拉根前言：将由溶度在0 mol %至24 mol %直接的1-棕榈酰-2-油酰-sn-甘油-3-磷酸胆碱 (POPC) 和有所差异溶度的1,2-二硬脂酰-sn-甘油-3-磷酸酒精胺-N-聚乙二醇-2000- N- [3-(2-吡啶基二硫代)丙酸酯] (DSPE-PEG-PDP) 构成的编织成单层囊泡拼装在氧原子级不平的文档模板剥落金 (TS Au) 外表。的使用氧原子力显微镜观察 (AFM) 对缓冲区液时所得枷锁脂质双重膜 (tLBM) 实施力谱浅析，带来了管于机诫初始化失败随枷锁原子 DSPE-PEG-PDP 溶度发生变化的的信息。杨氏模量利用食用较近改进的 Sneddon 整治拟合曲线拟合力-凹印曲线拟合来肯定，该整治调节了来下侧栽培基质的业绩。在低含量下，杨氏模量达不到可以支持的 POPC LBM（即会直接地处物质基低上）。模量的影响归因于膜还是流动性风险性的提高，会因为利用掺加 DSPE-PEG-PDP 约束基团，tLBM 和物质基低间的合体减轻了。从判断的杨氏模量值推测，含量大于 6 mol % 时，PEG 链构象判断 tLBM 的 刚性轨道。AFM 力谱数据介绍介绍反映出，聚乙二醇 (PEG) 白蘑菇到钢刷的转换成再次发生在 6 mol % 附近小区，这引发 tLBM 在更强的 DSPE-PEG-PDP 含量下先软化，最后没预兆变硬，这与转换成光于。当 DSPE-PEG-PDP 含量提高到 24 mol % 时，AFM 形貌和杨氏模量貌似与另外个相强迫关； AFM 形貌形象与加厚盘架构相同，表中 DSPE-PEG-PDP 要进行隔离在盘的表面。

AbstractUnilamellar vesicles composed of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) with varying 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-poly(ethylene glycol)-2000-N-[3-(2-pyridyldithio) propionate] (DSPE-PEG-PDP) concentration between 0 mol % and 24 mol % were assembled on atomically flat template-stripped gold (TS Au) surfaces. Force spectroscopy, using an atomic force microscope (AFM), of the resulting tethered lipid bilayer membranes (tLBMs) in buffer provided information regarding mechanical response as a function of tethering molecule, DSPE-PEG-PDP, concentration. Young’s modulus was determined by fitting the force–indentation curve with a recently modified Sneddon model that corrects for contributions from the substrate underneath. At low concentrations, Young’s modulus is lower than that of a supported POPC LBM, i.e., directly sitting on a solid substrate. The decrease in modulus is attributed to increased membrane fluidity as coupling between the tLBM and solid substrate is reduced by the incorporation of DSPE-PEG-PDP tethering groups. From the determined Young’s modulus values, the PEG chain conformation is found to dominate tLBM rigidity at concentrations above 6 mol %. Analysis of AFM force spectroscopy data indicates that the poly(ethylene glycol) (PEG) mushroom to brush transition occurs near 6 mol %, and this leads to first softening and then abrupt stiffening of tLBMs at higher DSPE-PEG-PDP concentration associated with the transition. When DSPE-PEG-PDP concentration is increased to 24 mol %, AFM topography and Young’s modulus appear correlated with another phase transition; AFM topography images are consistent with a bilayer disk structure with DSPE-PEG-PDP segregated at the rim of the disk.石家庄杏彩体育平台 生物学供给有关于货品：DSPE-PEG-Cy5.5DSPE-PEG-Cy7DSPE-PEG-NBDDSPE-PEG-TRITCDSPE-PEG-ComarinDSPE-PEG-ICGDSPE-PEG-PyreneDSPE-PEG-Ce6DSPE-PEG-Cy3超过一篇文章介绍源于各个期刊杂志或文献资料，以免抄袭请找话题各位删掉！