期刊论文：适用原子核力谱法分析评估桎梏1-棕榈酰-2-油酰-sn-甘油-3-磷酸胆碱膜的杨氏模量连接：//pubs.acs.org/doi/abs/10.1021/jp505451h我们：王曦，罗伯特·N·桑德森‡雷吉娜·拉根小结：将由有机废气溶液浓度值在0 mol %至24 mol %相互间的1-棕榈酰-2-油酰-sn-甘油-3-磷酸胆碱 (POPC) 和有差异有机废气溶液浓度值的1,2-二硬脂酰-sn-甘油-3-磷酸工业乙醇胺-N-聚乙二醇-2000- N- [3-(2-吡啶基二硫代)丙酸酯] (DSPE-PEG-PDP) 组合而成的一层囊泡組裝在氧氧原子级整齐的模板开发分离金 (TS Au) 外面。在使用氧氧原子力体视显微镜 (AFM) 对没有响应液时所得绳束脂质双层线路膜 (tLBM) 去力谱介绍，带来了针对机械制造没有响应随绳束原子 DSPE-PEG-PDP 有机废气溶液浓度值改变的信心。杨氏模量利用便用最近的修饰的 Sneddon 模形线性拟合力-压印身材曲线来确实，该模形矫正了基以下基本材料的分享。在低盐氨水酸度下，杨氏模量不超可以支持的 POPC LBM（即简单应用于固态基低上）。模量的削减归因于膜流通性的加强，正是因为利用掺量 DSPE-PEG-PDP 束缚调教基团，tLBM 和固态基低左右的解耦可以减少了。从测试的杨氏模量值能知，盐氨水酸度远远超出 6 mol % 时，PEG 链构象考虑 tLBM 的钢性。AFM 力谱数据信息介绍反映出，聚乙二醇 (PEG) 菌菇到钢丝刷的形成情况在 6 mol % 火车站附近，这引发 tLBM 在越高的 DSPE-PEG-PDP 盐氨水酸度下先变烂，随后太过突然变硬，这与形成关以。当 DSPE-PEG-PDP 盐氨水酸度加强到 24 mol % 时，AFM 形貌和杨氏模量仿佛与同一个相变向关； AFM 形貌图片与三层盘构成相符，各举 DSPE-PEG-PDP 防护在盘的非核心。

AbstractUnilamellar vesicles composed of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) with varying 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-poly(ethylene glycol)-2000-N-[3-(2-pyridyldithio) propionate] (DSPE-PEG-PDP) concentration between 0 mol % and 24 mol % were assembled on atomically flat template-stripped gold (TS Au) surfaces. Force spectroscopy, using an atomic force microscope (AFM), of the resulting tethered lipid bilayer membranes (tLBMs) in buffer provided information regarding mechanical response as a function of tethering molecule, DSPE-PEG-PDP, concentration. Young’s modulus was determined by fitting the force–indentation curve with a recently modified Sneddon model that corrects for contributions from the substrate underneath. At low concentrations, Young’s modulus is lower than that of a supported POPC LBM, i.e., directly sitting on a solid substrate. The decrease in modulus is attributed to increased membrane fluidity as coupling between the tLBM and solid substrate is reduced by the incorporation of DSPE-PEG-PDP tethering groups. From the determined Young’s modulus values, the PEG chain conformation is found to dominate tLBM rigidity at concentrations above 6 mol %. Analysis of AFM force spectroscopy data indicates that the poly(ethylene glycol) (PEG) mushroom to brush transition occurs near 6 mol %, and this leads to first softening and then abrupt stiffening of tLBMs at higher DSPE-PEG-PDP concentration associated with the transition. When DSPE-PEG-PDP concentration is increased to 24 mol %, AFM topography and Young’s modulus appear correlated with another phase transition; AFM topography images are consistent with a bilayer disk structure with DSPE-PEG-PDP segregated at the rim of the disk.绵阳杏彩体育平台 海洋生物出示对应护肤品：DSPE-PEG-Cy5.5DSPE-PEG-Cy7DSPE-PEG-NBDDSPE-PEG-TRITCDSPE-PEG-ComarinDSPE-PEG-ICGDSPE-PEG-PyreneDSPE-PEG-Ce6DSPE-PEG-Cy3之上稿件信息内容的来源四种刊物或文献综述，予以商标侵权请联系起来咱们卸载！