文章：线粒体、溶酶体和内质网：每个是光疗的最宜靶点？图片链接：//www.sciencedirect.com/science/article/abs/pii/S0168365922006320诗人：李艳红 ，贾浩然 ，王洪 银，华先武 ，鲍彦文 ，吴福 根节选：文献综述光驱能源自然疗法(PDT) 有的是种庞大的胃癌冶疗途径，其亚神经元核的作用位点的高精度失控设定对其效果性至关必要。因此，精确性无误相当不一样的神经元核器靶向疗法疗法药物 PDT 的办法的药效还具有挑戰性，如果真难查到一位简单的操作系统也可以实行对不一样的神经元核器的多个靶向疗法疗法药物性、可分离处理的时窗和相类似的紧密联系量。与此，我将二氢卟酚 e6 (Ce6) 与 1,2-二硬脂酰-sn-甘油-3-磷酸甲醇胺-N- [氨基(聚乙二醇)-5000]（铵盐）（DSPE-PEG 5000 -NH 2）偶联拥有 DSPE-PEG-Ce6，其在神经元核内化后也可以从线粒体移迁到溶酶体，终于到内质网 (ER)。致力于DSPE-PEG-Ce6亚神经元核分布不均的静态性相应其与神经元核器紧密联系量的随意调节性，我精确性无误地认定了该氧分子的光驱能源冶疗（PDT）药效顺序图，即线粒体 > 内质网 > 溶酶体。本实验提出来打了个位很好的模型工具操作系统，可以使用于精确性无误评定相应神经元核器靶向疗法疗法药物的光驱能源冶疗（PDT）药效，并已成定局提高的前景效果光驱能源冶疗方法的进展。AbstractPhotodynamic therapy (PDT) is a robust cancer treatment modality, and the precise spatiotemporal control of its subcellular action site is crucial for its effectiveness. However, accurate comparison of the efficacy of different organelle-targeted PDT approaches is challenging since it is difficult to find a single system that can achieve separate targeting of different organelles with separable time windows and similar binding amounts. Herein, we conjugated chlorin e6 (Ce6) with 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-5000] (ammonium salt) (DSPE-PEG5000-NH2) to afford DSPE-PEG-Ce6, which could migrate from mitochondrion to lysosome and ultimately to endoplasmic reticulum (ER) after cellular internalization. Benefiting from the dynamic subcellular distribution of DSPE-PEG-Ce6 with tunable organelle-binding amounts, we accurately determined the PDT efficacy order of the molecule, i.e., mitochondrion > ER > lysosome. This work proposes an ideal model system for accurately evaluating the specific organelle-targeted PDT efficacy and may promote the future development of effective PDT strategies.

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