专著：PLGA-卵磷脂-PEG核壳納米再生颗粒代替癌病靶向药物*网页链接：//www.worldscientific.com/doi/abs/10.1142/S1793984411000359诗人：娇艳， 里克·奥克塔维安蒂·托伊普， 陶鹏， 和 林诗琳引言：让让我们有关报道好几个种多业务能力聚乳酸-酒精酸共聚物 (PLGA)-卵磷脂-聚乙二醇 (PEG) 核壳納米激光束 (NPs)，该納米激光束包括脂质体和配位水滑石納米激光束的优越性，快速可用于递送肿瘤放疗化疗用量。该納米激光束的粒级、表皮电势和表皮官能团可使用多种配量基本参数轻易的调节，且反复性好，列如 脂质/配位水滑石、1,2-二硬脂酰-sn-甘油-3-磷酸酒精胺 (DSPE)-PEG- COOH /卵磷脂、DSPE-PEG- COOH /DSPE-PEG- NH 2 的质比、 DSPE-PEG 端基的绘制。让让我们将对模型肿瘤放疗化疗用量——亲水溶性顺铂 (DDP) 或疏水溶性 DDP 前药——封装类型于納米颗粒物状 (NP) 中，数据屏幕上显示其包封率高、不稳性佳、对高 FA 感觉形容的 MCF-7 血细胞核极具炎症因子朋友靶向治疗类药辨别的业务能力，且 FA 感觉形容量高，且血细胞核毒素较小。某些 PLGA-卵磷脂-PEG 核壳納米颗粒物状 (NP) 已被证实也是种*具成长性的癌症晚期靶向治疗类药*用量递送納米各种载体。Abstract：Protein cages have been widely investigated as molecular drug carrier. E2 protein from Bacillus stearothermophillus forms a dodecahedral cage structure of approximately 24 nm in diameter. To formulate a sustainable release profile, E2 protein was further encapsulated into poly(lactide-co-glycolide) (PLGA) microparticles to form a composite structure using water-in-oil-in-water (W/O/W) double emulsion method. The influence of fabrication parameters on microparticle morphology and E2 protein release profile were investigated. The microparticle size increased when the stirring speed of the second emulsification decreased. Decrease in the volume of external aqueous phase led to the reduction of microparticle size without affecting its porosity. The higher ionic concentration of external aqueous phase in the presence of surfactant resulted in microparticles with closed pores on surface. Increase in polymer concentration also led to the formation of less porous microparticles. The E2 protein was not dissociated upon encapsulation into PLGA microparticles based on the unchanged particle size of E2 protein. E2 protein release was studied in phosphate-buffered saline solution at 37°C. The initial burst and release rate were lowered as the surfactant concentration in external water phase during the fabrication process was increased from 0.1% to 1% (w/v). After 14-day incubation, no observable polymer degradation was found while the surface of microparticles appeared to be smoother than before incubation.

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