参考文献：Targeting Fluorescence Imaging of RGD-Modified Indocyanine Green Micelles on Gastric Cancer学术论文的链接：//www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2020.575365/full做者：Jun Shao&#x;Jun Shao1†Xiaoming Zheng&#x;Xiaoming Zheng1†Longbao FengLongbao Feng2Tianyun LanTianyun Lan3Dongbing DingDongbing Ding1Zikai CaiZikai Cai1Xudong ZhuXudong Zhu1Rongpu LiangRongpu Liang1Bo Wei*Bo Wei1*

As shown in Scheme 1, first, DSPE-PEG-RGD was obtained based on the Michael addition reaction between RGD peptide and DSPE-PEG-Mal. Second, the NIR agent ICG was encapsulated by the DSPE-PEG-RGD matrix via the self-assembly method. DSPE-PEG-Mal is an amphiphilic polymer. PEG serves as a hydrophilic unit to form the shell while DSPE is a hydrophobic unit to form the hydrophobic cavity with ICG in the core. The synthesis and Characteristics of DSPE-PEG-RGD@ICG were analyzed, including 1H NMR spectroscopy, transmission electron microscope (TEM), and so on. Then, the cellular uptake and biocompatibility were assessed. In addition, by using an optical imaging system, we observed the biodistribution and improved accumulation of DSPE-PEG-RGD@ICG in the tumor. The results of this study may provide a promising nanocarrier to realize the future clinical application of optical molecular imaging in early diagnosis and accurate resection of GC.

前提是，经由RGD肽和DSPE-PEG-Mal期间的Michael增益生理反应领取DSPE-PEG-RGD。此外，经由自折装方式已近红外化学药品ICG包封在DSPE-PEG-R GD栽培基质中。DSPE-PEG-Mal不是种两亲性汇聚物。PEG最为亲水单无式养成机壳，而DSPE最为疏水单无式养成疏水腔，ICG最靠近管理处。结合及特征参数DSPE-PEG-RGD@ICG用1H NMR光谱仪、散发出微电子体视显微镜（TEM）等开始深入分析，再监测体细胞摄入和动物相融性。除此以外，凭借便用光电技术显像软件，.我仔细观察了DSPE-PEG-RGD@ICG在良性肿瘤中。本论述的导致或许为实行光电技术原子显像在GC旱期测试和确切切掉中的未来的发展临床护理应用软件提高有行业前景的纳米级媒体。

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