期刊论文：Design of pH-sensitive methotrexate prodrug-targeted curcumin nanoparticles for efficient dual-drug delivery and combination cancer therapy文章联结：//www.tandfonline.com/doi/full/10.2147/IJN.S152312#d1e205原作者：Jiajiang Xie,Zhongxiong Fan,Yang Li,Yinying Zhang,Fei Yu,Guanghao Su绪论：AimWe designed acid-labile methotrexate (MTX) targeting prodrug self-assembling nanoparticles loaded with curcumin (CUR) drug for simultaneous delivery of multi-chemotherapeutic drugs and combination cancer therapy.MethodsA dual-acting MTX, acting as both an anticancer drug and as a tumor-targeting ligand, was coupled to 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[aldehyde(polyethylene glycol)-2000] via Schiff’s base reaction. The synthesized prodrug conjugate (DSPE-PEG-Imine-MTX) could be self-assembled into micellar nanoparticles (MTX-Imine-M) in aqueous solution, which encapsulated CUR into their core by hydrophobic interactions (MTX-Imine-M-CUR).

数据制得的MTX-Imine-M-CUR微米颗粒物由实物疏水溶性DSPE/CUR重要和间接亲水溶性双羟基聚乙二醇（PEG）的金属外壳包含，的金属外壳享有自靶向治疗MTX前药冠。1,2-二硬脂酰-sn-甘油-3-磷酸乙酰胺-N-[醛（聚乙二醇）-2000]和MTX区间内的亚胺连结体为动态性共价键，满足强，即便是在酸碱性pH下高速 裂解，在生理变化pH下还能稳定完美。MTX-imine-M-CUR会依据叶酸片蛋白激酶介导的内吞反应选性有效果地将MTX和CUR编码查询到肺癌生殖细胞中，陆陆续续依据内体/溶酶体的酸碱性高速 放CUR和活力手段的MTX。再者，MTX-Imine-M-CUR在身体之外和体内的的*癌催化活性看不出远远超出pH不脆弱的额定过载CUR的DSPE-PEGAmide-MTX拼装奈米小粒（MTX-Amide-M-CUR）、额定过载CUR（M-CUR）的MTX非偶联DSPE-PEG拼装胶束奈米小粒、多种分离性药的乐队组合和单一个分离性药。有关于引荐：TAT-PEG-DSPECy3-iRGD-PEG-DSPEFITC-iRGD-PEG-DSPER8-PEG-DSPEAngiopep-2-PEG-DSPEFITC-Angiopep-2-PEG-DSPETH-PEG-DSPER6H4-PEG-DSPE往上稿件內容来原常见期刊论文或论文资料，请谅解侵权行为请联系起来大家误删！