DSPE-PEG-FA修饰纳米颗粒用于增强肿瘤细胞摄取与核定位释放
DSPE-PEG-FA突显微米颗粒肥料用以提高*上皮细胞摄取量与审核位挥发链接转换://pubs.acs.org/doi/abs/10.1021/acsami.5b05038笔者:杨丽,林金艳,杨瑞祥,李彦修,吴世超,玉皇,叶社芳,谢丽娅,戴理宗,侯真庆提要:紧密联系丝裂霉素C (MMC)–磷脂结合物可提升食用的药材包封率并减小食用的药材过快挥发移除和DSPE-PEG-DHA (DSPE-PEG-FA) 能用于特男人靶向疗法药材*的强势,你们新闻了一大大种简洁的一锅自組裝路径来提纯放有MMC–磷脂结合物的DSPE-PEG基微米粒子 (MP-PEG-FA NPs)。共准确把握显像和普鲁士蓝染色肿瘤肿瘤人体受损细胞术均证明,在肿瘤肿瘤人体受损细胞摄入和肿瘤肿瘤人体受损细胞内食用的药材递送后,MMC规划到肿瘤肿瘤人体受损细胞质中。更为重要的是,全身性给药的MP-PEG-FA NPs可提升HeLa*裸鼠的动脉血持续性性和怎强的*蓄积。本调查介紹了一大大种简洁有效果的策咯来开发依托于*癌食用的药材–磷脂结合物的靶向疗法药材食用的药材递送设计,以保持持续性/有效控制的食用的药材挥发移除。原文翻译:Integrating advantages of mitomycin C (MMC)–phospholipid complex for increased drug encapsulation efficiency and reduced premature drug release, DSPE-PEG-folate (DSPE-PEG-FA) for specific tumor targeting, we reported a simple one-pot self-assembly route to prepare the MMC–phospholipid complex-loaded DSPE-PEG-based nanoparticles (MP-PEG-FA NPs). Both confocal imaging and flow cytometry demonstrated that MMC was distributed into nuclei after cellular uptake and intracellular drug delivery. More importantly, the systemically administered MP-PEG-FA NPs led to increased blood persistence and enhanced tumor accumulation in HeLa tumor-bearing nude mice. This study introduces a simple and effective strategy to design the anticancer drug–phospholipid complex-based targeted drug delivery system for sustained/controlled drug release.