DSPE-PEG-FA掩盖纳米级粉末于明显增强*上皮细胞摄食与核算位放出链接搜索：//pubs.acs.org/doi/abs/10.1021/acsami.5b05038小说家：杨丽，林金艳，杨瑞祥，李彦修，吴世超，玉皇，叶社芳，谢丽娅，戴理宗，侯真庆绪论：结合实际丝裂霉素C (MMC)–磷脂pp物可加剧中成药包封率并少中成药早点宣泄各类DSPE-PEG-DHA (DSPE-PEG-FA) 需用于特异形靶点*的优劣势，让我们消息一种方便的一锅自拼装规划来制得乘载MMC–磷脂pp物的DSPE-PEG基奈米颗粒肥料 (MP-PEG-FA NPs)。共准确把握影像和流式的组织术均取决于，在组织摄食和组织内中成药递送后，MMC布局到组织核中。更比较重要的是，周身给药的MP-PEG-FA NPs可加剧HeLa*裸鼠的动脉血耐久性和资料的*蓄积。本探讨推荐一种方便可行的战略来设置根据*癌中成药–磷脂pp物的靶点中成药递送系统，以保证连续/的控制的中成药宣泄。古诗网：Integrating advantages of mitomycin C (MMC)–phospholipid complex for increased drug encapsulation efficiency and reduced premature drug release, DSPE-PEG-folate (DSPE-PEG-FA) for specific tumor targeting, we reported a simple one-pot self-assembly route to prepare the MMC–phospholipid complex-loaded DSPE-PEG-based nanoparticles (MP-PEG-FA NPs). Both confocal imaging and flow cytometry demonstrated that MMC was distributed into nuclei after cellular uptake and intracellular drug delivery. More importantly, the systemically administered MP-PEG-FA NPs led to increased blood persistence and enhanced tumor accumulation in HeLa tumor-bearing nude mice. This study introduces a simple and effective strategy to design the anticancer drug–phospholipid complex-based targeted drug delivery system for sustained/controlled drug release.

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